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B7-H3(B7RP-2,CD276)是新近鉴定的对淋巴细胞存活及活化、NK细胞及成骨细胞的发育等都具有重要调节作用的B7家族共刺激分子。最近的研究则显示,B7-H3还高表达于各种类型的肿瘤组织中并参与了肿瘤的发生及发展。本文就B7-H3的生理功能及其在肿瘤免疫中的最新进展做一综述。
B7-H3 (B7RP-2, CD276) is a newly identified B7 family of co-stimulatory molecules that have an important regulatory role on lymphocyte survival and activation, NK cell and osteoblastic development. Recent studies have shown that B7-H3 is also highly expressed in various types of tumor tissues and is involved in the occurrence and development of tumors. This article reviews the physiological functions of B7-H3 and its recent advances in tumor immunity.