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目的:了解我院药物标示外使用的情况及其合理性,促进临床合理用药。方法:收集我院2008年10月13日—2008年10月24日(不含周六、周日)门诊处方,共计21 716张,与说明书中规定的适应证、给药剂量、给药频率、给药途径等对比,筛查所有处方,并将标示外用药处方进行统计。通过药品说明书、研究文献等,对标示外处方进行分析,找出其中不合理的地方。结果:院内标示外用药处方占所有处方的23.2%,涉及药品73个。其中适应证外用药345例,包括药品9个;批准用法用量以外用药4 645例,包括药品55个;批准给药途径以外用药39例,包括药品9个。统计中发现存在一些不合理的标示外用药,包括无证据的适应证外用药,一些大剂量用药,给药频率、给药时间及给药途径不合理。结论:标示外用药需要医生和药师共同关注,遵循安全第一,充分知情,权衡利弊,循证使用的原则。
Objective: To understand the use of drugs outside the hospital marked the case and its rationality, to promote clinical rational use of drugs. Methods: Outpatient prescriptions were collected from October 13, 2008 to October 24, 2008 (excluding Saturday and Sunday) in our hospital for a total of 21 716 prescriptions, and the indications, dosage, frequency of administration , Route of administration and so on, screening all prescriptions, and prescriptions prescriptions for statistics. Through the drug manuals, research literature, etc., to identify the prescriptions outside the analysis to find out where the unreasonable. Results: In-hospital prescriptions accounted for 23.2% of all prescriptions, involving 73 pharmaceuticals. Among them, 345 cases of external use indications, including 9 drugs, were approved; 4 645 cases of drugs other than the approved dosage were approved, including 55 drugs; 39 cases were approved for administration outside the administration route, including 9 drugs. Statistics found that there are some unreasonable labeling of topical drugs, including non-evidence of indications for external use drugs, some large doses of medication, frequency of administration, administration time and route of administration unreasonable. Conclusion: The labeling of topical drugs requires the mutual attention of doctors and pharmacists, following the principle of safety first, full knowledge, weighing the pros and cons and using evidence-based.