雷公藤为卫矛科雷公藤属植物,临床上用于治疗多种炎性、变应性、自身免疫性疾病,疗效可靠,但毒性较大。近年来,我所从雷公藤中分离得到一个新的化学组分——雷公藤多甙(T_Ⅱ)。对此,我们进行了一系列的药理及毒理研究。现将研究结果并结合其它有关资料综述如下。药理作用一、抗炎作用1.雷公藤多甙(T_Ⅱ)对多种炎症模型有效,能显著抑制大鼠琼脂关节肿,组织胺致毛细血 Tripterygium wilfordii Tripterygium genus, clinically used for the treatment of a variety of inflammatory, allergic, autoimmune diseases, efficacy is reliable, but more toxic. In recent years, I have isolated from Tripterygium a new chemical composition - Tripterygium glycosides (T_ Ⅱ). In this regard, we conducted a series of pharmacological and toxicological studies. Now the research results combined with other relevant information summarized below. Pharmacological effects First, the anti-inflammatory effect 1. Tripterygium glycosides (T_Ⅱ) on a variety of inflammatory models, can significantly inhibit the rat agar swollen, histamine induced capillary