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肿瘤发生是一个多步骤过程。绝大多数人肿瘤由产生了系列相继变化的单一细胞形成。这些变化导致细胞有丝分裂信号或生长控制的细微异常 ,逐步赋予细胞赘生的特性 ,直至细胞形成恶性肿瘤。防御肿瘤发生的一个重要机能是诱导细胞死亡 ,这种机能持续不断地清除机体内多余的 ,受损的或变异的细胞。对肿瘤细胞增殖优势的分子机理的认识 ,揭示了许多肿瘤细胞如何应答异常有丝分裂信号的内在现象 ,而蛋白磷酸激酶是介导这些信号通路的主体。天然细胞或病毒蛋白能作为细胞死亡效应子发挥作用 ,尤其有意义的是 ,有些细胞和病毒蛋白具有肿瘤特异性细胞死亡效应 ,可望发展成为新的抗肿瘤治疗制剂。
Tumorigenesis is a multi-step process. The vast majority of tumors are formed by a single cell that produces a series of sequential changes. These changes lead to subtle abnormalities in mitotic signals or growth control, gradually giving the cell neoplastic properties until the cells form malignant tumors. An important function of defense against tumorigenesis is to induce cell death, a function that continually removes excess, damaged or aberrant cells in the body. The understanding of the molecular mechanisms of tumor cell proliferation superiority reveals how many tumor cells respond to the intrinsic phenomena of aberrant mitotic signals, and protein phosphatases are the agents that mediate these signaling pathways. Natural cells or viral proteins can act as cell death effector, and in particular, some cells and viral proteins have tumor-specific cell death effects and are expected to develop into new anti-tumor therapeutic agents.