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目的观察丹参对糖尿病早期肾病患者血浆内皮素 ( ET-1 )、IV型胶原 ( CIV)的影响。方法将 6 6例患者随机分为丹参治疗组 ( 3 6例 )和常规治疗组 ( 3 0例 ) ,另选 2 1例健康人作正常对照。常规治疗组给糖尿病饮食 ,正规皮下注射胰岛素 ;而丹参治疗组在上述治疗基础上加用丹参注射液 2 0 ml静滴 ,每日 1次 ,于治疗 4周后测定血糖 ( FBS) ,糖化血红蛋白 ( Hb AIC)、ET-1、CIV和 2 4小时尿白蛋白排泄率 ( UAER)水平。结果糖尿病肾病患者血浆 ET-1、CIV水平明显高于健康对照 ( P<0 .0 1 ) ;随着血糖的控制 ,ET-1、CIV和 2 4小时 U AER水平均不同程度降低 ,丹参治疗组下降更明显 ( P<0 .0 5 )。结论血浆 ET-1、CIV水平的升高可能是促进糖尿病肾病发生发展的重要因素 ,而丹参可抑制 ET-1产生和 CIV的合成 ,对糖尿病肾病的早期防治有一定作用
Objective To observe the effects of salvia miltiorrhiza on plasma endothelin (ET-1) and type IV collagen (CIV) in patients with early diabetic nephropathy. Methods Sixty-six patients were randomly divided into the Salvia miltiorrhiza treatment group (36 cases) and the conventional treatment group (30 cases). Another 21 healthy individuals were selected as normal controls. In the conventional treatment group, a diabetic diet was administered, and insulin was administered subcutaneously; while in the Danshen treatment group, 20 ml of Danshen injection was intravenously infused on a daily basis, and blood glucose (FBS), glycosylated hemoglobin was measured after 4 weeks of treatment. (Hb AIC), ET-1, CIV, and 24 hour urinary albumin excretion rate (UAER) levels. Results Plasma levels of ET-1 and CIV in patients with diabetic nephropathy were significantly higher than those in healthy controls (P<0.01). With the control of blood glucose, ET-1, CIV and 24-hour U AER levels decreased to varying degrees. Salvia miltiorrhiza treatment The group decreased more significantly (P < 0.05). Conclusion The increase of plasma ET-1 and CIV levels may be an important factor in promoting the development of diabetic nephropathy. Salvia miltiorrhiza can inhibit the synthesis of ET-1 and CIV and play a role in the early prevention and treatment of diabetic nephropathy.