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按ARA诊断标准选择病情进展期类风湿性关节炎(MRA组)22例,病情稳定期(RA组)29例,健康成人16例。分别检测血沉(ESR)、血浆凝血酶原时间(PT)、纤维蛋白原定量(FIB)、血小板计数(PLT)、纤维蛋白降解产物(FDP)、凝血酶-抗凝血酶Ⅲ复合物(TAT)、纤溶酶-α2抗纤溶酶抑制物复合物(PLC)、血栓调节素(TM)。见到MAR组的ESR、FDP、PIC、TM均显著高于RA组和对照组;在MRA和RA组又见到ESR与FDP、PIC、TM,及FDP与TAT之间呈正相关。提示在类风湿症时,由于免疫功能异常,导致血管炎和凝血、纤溶性增强,PIC和TM可以作为类风湿症合并血管炎诊断与治疗的重要指标之一。
According to ARA diagnostic criteria, 22 patients with advanced rheumatoid arthritis (MRA group), 29 patients with stable disease (RA group) and 16 healthy adults were selected. ESR, PT, FIB, PLT, FDP, TAT ), Plasmin-α2 anti-plasmin inhibitor complex (PLC), thrombomodulin (TM). ESR, FDP, PIC and TM in MAR group were significantly higher than those in RA group and control group. There was a positive correlation between ESR and FDP, PIC, TM, FDP and TAT in MRA and RA group. Prompt rheumatoid disease, due to abnormal immune function, leading to vasculitis and coagulation, fibrinolysis increased, PIC and TM can be used as rheumatoid arthritis vasculitis diagnosis and treatment of one of the important indicators.