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目的 :研究泮托拉唑不同剂量或不同给药方式对十二指肠球溃疡患者胃内 pH值的影响。 方法 :采用随机对照法。 2 4例内镜确诊为十二指肠球溃疡的患者随机分为 3组 ,每组 8例。分别接受泮托拉唑静脉点滴4 0mg ,qd ;80mg ,qd ;4 0mg ,q12h。于用药后d2连续 2 4h监测患者胃内 pH值。结果 :3组起效时间均较快 ,各组间无显著性差异。 80mg ,qd组 2 4h胃内pH值 >3的总时间、pH >4的总时间、pH >6的总时间及平均pH值均高于其他 2组 ,有显著性差异 (P <0 .0 5 )。而 4 0mgq12h与 4 0mgqd差异无显著性。 结论 :泮托拉唑 80mg ,qd用药能较长时间维持较高的胃内 pH值 ,对消化性溃疡的治疗尤其是合并出血时治疗可能效果更好。
Objective: To study the effects of pantoprazole in different dosages or doses on gastric pH in patients with duodenal ulcer. Methods: Randomized controlled trial. Twenty-four patients with endoscopic diagnosis of duodenal ulcer were randomly divided into 3 groups of 8 patients. Respectively, receiving pantoprazole intravenous drip 40mg, qd; 80mg, qd; 40mg, q12h. In patients with d2 continuous monitoring of gastric pH 24h after treatment. Results: The onset time of the three groups was fast, no significant difference between the groups. The total time of pH> 4, the total time of pH> 6 and the average pH value of 80mg and qd groups were significantly higher than those of other two groups (P <0. 0 5). While 4 0mgq12h and 40mgqd no significant difference. Conclusion: Pantoprazole 80mg, qd medication for a long time to maintain a high gastric pH, the treatment of peptic ulcer bleeding, especially with bleeding may be better.