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类固醇激素、核受体及其辅助因子在细胞增殖、分化中起重要的作用。核受体与相应的配体结合后同细胞内的辅助激活因子CBP/P30 0、PCAF、P/CIP和SRC家族等结合形成的复合物能使组蛋白乙酰化促进基因的转录。当缺乏配体时核受体同辅助抑制因子SMRT、mSin3A及HAD1具有很强的结合力使组蛋白去乙酰化抑制基因的转录活性。MAPK、PKA、AP 1、Sap a、JAK/STAT、JAK信号传导中核受体辅助因子参与信号传导过程影响基因的转录
Steroid hormones, nuclear receptors and their cofactors play an important role in cell proliferation and differentiation. The binding of nuclear receptors to the corresponding ligands and complexes with the intracellular co-activators CBP / P30 0, PCAF, P / CIP and SRC families, enables the histone acetylation to promote the transcription of genes. In the absence of ligand, the nuclear receptor binds to the helper suppressors SMRT, mSin3A and HAD1 with a strong binding force that allows histone deacetylation to suppress the transcriptional activity of the gene. Nuclear receptor cofactors in MAPK, PKA, AP 1, Sap a, JAK / STAT and JAK signaling are involved in signal transduction processes affecting gene transcription