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目的:调查河南地区21种人乳头状瘤病毒基因型的分子流行病学特点。方法:收集2 568例女性宫颈病变患者宫颈分泌物中的脱落细胞,应用人乳头状瘤病毒导流杂交快速基因分型技术检测21种人乳头状瘤病毒亚型,包括13种高危亚型(16,18,31,33,35,39,45,51,52,56,58,59和68型)、5种低危亚型(6,11,42,43和44型)和3种中国人群常见亚型(53,66和CP8304型);分析21种基因型的流行病学特点。结果:人乳头状瘤病毒感染率41.6%,单一感染率57.7%,混合性感染率42.3%。21种基因型中,高危型以16,31型为主,其次是52,58型,低危型以6,11型为主;人乳头状瘤病毒16型的感染率居首位。结论:本地区21种人乳头状瘤病毒基因型的分子流行病学资料对人乳头状瘤病毒疫苗研究、应用及其感染的防治有重要意义。
Objective: To investigate the molecular epidemiological characteristics of 21 human papilloma virus genotypes in Henan Province. Methods: Twenty-five human papillomavirus (HPV) exfoliated cells were collected from cervical secretions. Rapid detection of 21 human papillomavirus subtypes by flow-mediated hybridization of human papillomavirus (HPV), including 13 high-risk subtypes 35, 49, 45, 51, 52, 56, 58, 59 and 68), 5 low risk subtypes (6, 11, 42, 43 and 44) The common subtype of the population (53,66 and CP8304 type); analysis of the epidemiological characteristics of 21 genotypes. Results: The HPV infection rate was 41.6%, the single infection rate was 57.7% and the mixed infection rate was 42.3%. Of the 21 genotypes, high-risk type was mainly 16,31, followed by type 52,58, low-risk type was type 6 and type 11. Human papillomavirus 16 infection rate was the highest. Conclusion: The molecular epidemiological data of 21 human papillomavirus genotypes in this region are of great significance to the research, application and prevention and cure of human papillomavirus (HPV) vaccine.