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目的:探讨国产托烷司琼治疗由顺铂(DDP)引起的消化道反应的临床疗效。方法:采用多中心、随机、自身交叉对照的方法,对72例接受含顺铂的联合化疗肿瘤患者,随机分为A、B两组。止吐方案:国产托烷司琼5mg,静滴,第1～5天,欧必亭5mg,静滴,第1～5天。结果:国产托烷司琼控制急性呕吐(第1～3天)的有效率分别为96.9%(63/65)、89.2%(58/65)、81.5%(53/65),欧必亭控制急性呕吐(第1～3天)的有效率分别为96.9%(63/65)、90.8%(59/65)、83.1%(54/65),两组无统计学差异(P>0.05)。国产托烷司琼控制第4～5天呕吐的有效率分别为73.8%、81.5%,欧必亭控制第4～5天呕吐的有效率分别是80.0%、83.1%,无统计学差异(P>0.05)。两组不良反应相似。未见头痛、腹部不适及锥体外系症状发生。结论:国产托烷司琼与欧必亭治疗以顺铂为主的化疗方案所致的恶心、呕吐,均取得相似的效果,且不良反应轻微,具有很好的耐受性,可作为预防含有顺铂联合化疗所致恶心、呕吐的一线治疗。
Objective: To investigate the clinical efficacy of domestic tropisetron in the treatment of digestive tract reactions induced by cisplatin (DDP). Methods: A multicenter, randomized, self-controlled crossover study was conducted in 72 patients with cisplatin-containing combination chemotherapy and were randomly divided into A and B groups. Antiemetic program: domestic tropisetron Joan 5mg, intravenous infusion, the first 1 to 5 days, European Pavilion 5mg, intravenous infusion, the first 1 to 5 days. Results: The efficiencies of domestic tropisetron in controlling acute vomiting (days 1 to 3) were 96.9% (63/65), 89.2% (58/65) and 81.5% (53/65), respectively. The effective rates were 96.9% (63/65), 90.8% (59/65) and 83.1% (54/65) respectively. There was no significant difference between the two groups (P> 0.05). Efficacy of domestically produced tropisetron on vomiting from day 4 to day 5 was 73.8% and 81.5%, respectively. The effective rates of emesis from day 4 to day 5 were 80.0% and 83.1%, respectively, with no statistical difference (P> 0.05 ). The two groups had similar adverse reactions. No headache, abdominal discomfort and extrapyramidal symptoms occurred. CONCLUSION: Domestic tropisetron and ophibitine have similar effects in the treatment of cisplatin-based chemotherapy regimens with nausea and vomiting, with mild adverse reactions and good tolerability. Combined chemotherapy lead to nausea and vomiting of first-line treatment.