瘤型(LL)麻风患者的特征是缺乏对麻风菌的细胞免疫反应(CMR),甚至经过长期治疗、皮肤查菌阴性后,其麻素试验,淋巴细胞转化试验等仍然阴性。LL 患者治疗前也可有非特异性 CMR 的部分缺陷,但治疗后可有所恢复。LL 患者经长期砜类药物治疗后仍能检出少量活菌。估计这种“持久菌”的存在至少部分是由于宿主针对麻风菌的特异性CMR 缺陷。因此欲清除这些“持久菌”,除化疗外尚需重建宿主对麻风菌的 CMR 能力。本文作者此前已报告过健康者用灭活的麻风菌 Patients with leprosy (LL) are characterized by a lack of cellular immune response (CMR) to leprosy and, even after long-term treatment, dermatitis and neutrophil tests, their neutrophil test, lymphocyte transformation test and the like remain negative. LL patients may also have partial defects in non-specific CMR before treatment, but may recover after treatment. LL patients can still detect a small amount of live bacteria after long-term sulfone treatment. The presence of this “persimmon” is estimated at least in part due to the host’s specific CMR deficiency on leprosy. Therefore, to remove these “persistent bacteria”, in addition to chemotherapy, it is still necessary to reconstruct the CMR capacity of the host against leprosy. The authors of this article have previously reported healthy people with inactivated leprosy