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含脯氨酸的小肽的结构分析工作,有助于了解由亚氨基形成的肽键的性质、脯氨酸氮戊环的构型及其对肽链转折的影响等。目前,这方面的结构数据还不多,我们试图通过L-脯氨酰—甘氨酸,甘氨酰—L-脯氨酸等简单物质的结构分析,进一步积累这方面的资料。本文先报导L-脯氨酰—甘氨酸结构分析的初步结果。在水—乙醇溶液中培养出来的脯—甘二肽晶体属单斜晶系,空间群为P21,晶胞参数a=13.21A;b=5.38A;c=6.61A;β=101°12′。晶体密度的精密测定表明,每个晶胞除了含有两个脯甘二肽分子外,还应含有两个结晶水。用Weissenberg照相法收集了CuK_α波长范围内的全部三维衍射强度,并用目测法进行测量。原始
Structure analysis of small peptides with proline helps to understand the properties of peptide bonds formed by imino groups, the configuration of proline nitrogenopen rings and its effect on the transition of peptide chains. At present, there are not many structural data in this area. We have tried to further accumulate this data by structural analysis of simple substances such as L-prolyl-glycine and glycyl-L-proline. This article first reports the preliminary results of the structural analysis of L-prolyl-glycine. The crystal of Candida-glycyl peptide cultured in water-ethanol solution is monoclinic with space group P21, unit cell parameters a = 13.21A; b = 5.38A; c = 6.61A; β = 101 ° 12 ’ . The crystal density of the precision measurement shows that each cell in addition to containing two prolyl-peptide molecules, it should also contain two crystal water. All three-dimensional diffraction intensities in the CuK_α wavelength range were collected by Weissenberg photometry and visually measured. original