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３１例清洁择期后颅窝手术病人，术前静滴头孢曲松，于开颅时、关颅时取血液、脑脊液、瘤腔残液，用ＨＰＬＣ法测定其药物浓度，其平均浓度为：开颅时血液：９９．３２±４１．０５ｍｇ／Ｌ，关颅时血液：４６．８２±２４．４４ｍｇ／Ｌ，瘤腔残液：４５．２０±２２．８６ｍｇ／Ｌ，脑脊液：２．４１±１．９９ｍｇ／Ｌ。３１例受试者中有７例术后颅内感染，感染率２２．６％，各种体液的药物浓度在感染组与非感染组之间均无显著差异。有２例病人脑脊液药物浓度低于ＭＩＣ５０，但两人均未发生术后感染。本研究认为预防性抗生素应用量的多少不是后颅窝术后感染的主要原因，不需盲目加大预防性抗生素的用量
31 cases of patients with posterior cranial fossa surgery after elective cesarean section, preoperative intravenous ceftriaxone, when the craniotomy, blood, cerebrospinal fluid and tumor cavity residue were removed from the cranial cavity, and the drug concentration was determined by HPLC. The average concentration was Cranial blood: 99.32 ± 41.05mg / L, when the blood off the skull: 46.82 ± 24.44mg / L, tumor residue: 45.20 ± 22.86mg / L, cerebrospinal fluid: 2.41 ± 1.99 mg / L. Seven of 31 subjects had postoperative intracranial infection at a rate of 22.6%. There was no significant difference in drug concentrations of various body fluids between infected and non-infected patients. Two patients had cerebrospinal fluid drug concentrations below the MIC50, but neither had postoperative infection. This study suggests that the amount of prophylactic antibiotics is not the main reason for posterior fossa infection, do not blindly increase the amount of prophylactic antibiotics