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作者用鼠麻风菌(MLM)经皮下感染C_(57) BL/6和CBA/J小鼠,观察两种鼠感染MLM后脾脏重量,肝和脾脏中MLM增殖数量的变化,以及对MLM特异性抗原的超敏反应(DTH),以证实两种鼠对MLM的不同易感性及其机理。CBA/J小鼠脾脏中的菌数在感染后15周内持续增加,至感染后20周时,脏器中可见大量聚集的细菌,且菌数在整个观察时间内未见下降,脾重增加与菌数的增加相平行;感染15周的C57BL/6小鼠脾脏中MLM数量稍有增加,以后下降,在整个观察期
The authors inoculated C57BL / 6 and CBA / J mice subcutaneously with MLM to observe the changes of spleen weight, MLM proliferation in liver and spleen of MLML-infected mice and MLM-specific Antigen Hypersensitivity (DTH) was performed to demonstrate the different susceptibilities and mechanisms of MLM to the two mice. The number of bacteria in the spleen of CBA / J mice continued to increase within 15 weeks after infection. By the 20th week after infection, a large number of bacteria were found in the organs, and the number of bacteria did not decrease throughout the observation time and the spleen weight increased Parallel to the increase of the number of bacteria. The number of MLM in the spleen of C57BL / 6 mice infected with 15-week infection increased slightly and then decreased. During the whole observation period