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目的分析三联疗法治疗消化性溃疡临床疗效及对食管下括约肌的影响。方法随机双盲法将80例消化性溃疡患者分为两组,各40例,对照组采取单纯奥美拉唑治疗,观察组则行奥美拉唑+阿莫西林+克拉霉素治疗,两组均干预1周。比较两组临床疗效、幽门螺杆菌(Hp)根除率、不良反应及食管下括约肌相关指标。应用SPSS 19.0统计软件分析数据,计数资料用率(%)表示,采用χ2检验,计量资料用(xˉ±s)表示,采用t检验,P<0.05为差异有统计学意义。结果观察组治疗总有效率92.50%,对照组为87.50%,差异无统计学意义(P>0.05)。观察组Hp根除率90.00%,显著高于对照组的32.50%,差异有统计学意义(P<0.05)。两组治疗后食管下括约肌平均压力(LESP)、食管下括约肌长度(LESL)比较差异无统计学意义(P>0.05)。结论奥美拉唑+阿莫西林+克拉霉素三联疗法治疗消化性溃疡疗效明确,Hp根除率高,且对患者食管下括约肌影响不大。
Objective To analyze the clinical efficacy of triple therapy in the treatment of peptic ulcer and its effect on the lower esophageal sphincter. Methods Eighty patients with peptic ulcer were randomly divided into two groups (n = 40). The control group was treated with omeprazole alone. The observation group received omeprazole plus amoxicillin plus clarithromycin Group intervention for 1 week. The curative effect, eradication rate of Helicobacter pylori (Hp), adverse reactions and related indicators of lower esophageal sphincter were compared between the two groups. SPSS 19.0 statistical software was used to analyze the data, and the counting data was expressed as% (%). Chi-square test was used and measurement data was expressed as (xˉ ± s). Using t test, P <0.05 was considered statistically significant. Results The total effective rate was 92.50% in the observation group and 87.50% in the control group, with no significant difference (P> 0.05). The observation group Hp eradication rate was 90.00%, significantly higher than the control group of 32.50%, the difference was statistically significant (P <0.05). There was no significant difference in LESP and LESL between the two groups after treatment (P> 0.05). Conclusion omeprazole + amoxicillin + clarithromycin triple therapy for the treatment of peptic ulcer clear effect, Hp eradication rate is high, and the effect on patients with esophageal sphincter is not.