论文部分内容阅读
现已证实重症肌无力(MG)不仅是一种神经肌肉传导功能障碍的自体免疫性疾病,而且还常伴有中枢神经系统的功能紊乱.例如,MG患者与正常人群比较,其癫痫发病率显著增加;MG患者发病初期常伴有精神症状.也有学者发现,MG患者睡眠时,其快速眼动期(REM)持续的时间、数量减少.而且MG患者脑干听觉诱发电位发现Ⅳ-v复合波的波幅降低,这提示MG患者也具有对诱发反应“疲劳性”的特点.在实验研究方面,有人发现在部分MG患者的脑脊液中有乙酰胆硷受体抗体(AchR-Ab)的存在,并且还有单克隆和少克隆的IgG带.也有证据显
It has been demonstrated that myasthenia gravis (MG) is not only an autoimmune disease with neuromuscular conduction dysfunction but also is often accompanied by central nervous system dysfunction, for example, patients with MG have significantly higher seizure rates than normal subjects Increase; MG patients often accompanied early onset of psychiatric symptoms.Some scholars have found that MG patients sleep, the rapid eye movement (REM) lasting time, the number decreased.And MG patients with brainstem auditory evoked potentials found IV-v complex wave , Suggesting that patients with MG also have a response to “fatigue.” In experimental studies, it was found that the presence of acetylcholine receptor antibody (AchR-Ab) in the cerebrospinal fluid of some MG patients , And there are monoclonal and less cloned IgG bands. There is also evidence