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目的探讨米非司酮治疗围绝经期功能性子宫出血的临床疗效。方法随机选择56例围绝经期功能性子宫出血患者,给予米非司酮治疗3个月,观察用药前后临床症状改善情况以及血红蛋白、子宫大小、子宫内膜厚度变化。结果 56例患者在服药治疗后均出现暂时性闭经。有42例患者停药后直接进入绝经期,11例患者在停药后30～50d内月经来潮,月经周期恢复正常,经量减少,3例因病情反复而行子宫切除术,总有效率为94.6%。与治疗前比较,治疗后血红蛋白明显上升,子宫内膜厚度明显变薄(P<0.05)。结论米非司酮治疗围绝经期功能性子宫出血疗效确切,安全可靠。
Objective To investigate the clinical efficacy of mifepristone in the treatment of functional uterine bleeding during perimenopausal period. Methods Fifty-six patients with functional uterine bleeding during peri-menopause were randomly selected and treated with mifepristone for 3 months. The clinical symptoms, hemoglobin, uterine size and endometrial thickness were observed before and after treatment. Results 56 cases of patients after treatment are temporary temporary amenorrhea. 42 patients discontinued directly into the menopause, 11 patients within 30 ~ 50d after stopping menstrual cramps, menstrual cycle returned to normal, the amount decreased, 3 cases of hysterectomy because of repeated illness, the total effective rate was 94.6%. Compared with before treatment, hemoglobin after treatment increased significantly, the endometrial thickness was significantly thinner (P <0.05). Conclusion Mifepristone is effective, safe and reliable in the treatment of functional uterine bleeding in perimenopausal period.