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目的通过研究膜型基质金属蛋白酶-1(membrane type matrix metalloproteinase-1,MT1-MMP)及基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)在甲状腺乳头状癌组织及癌旁组织中的表达,探讨其表达在甲状腺乳头状癌发生发展中的意义。方法采用免疫组织化学SP法检测164例甲状腺乳头状癌及其癌旁组织标本中MT1-MMP和MMP-2的表达,分析二者的表达与甲状腺乳头状癌临床病理特征间的关系。结果在甲状腺乳头状癌癌旁组织中,MT1-MMP表达阳性率为11.0%(18/164),MMP-2表达阳性率为14.0%(23/164);在甲状腺乳头状癌组织中,MT1-MMP及MMP2的表达阳性率分别为61.6%(101/164)和67.7%(111/164);二者在癌组织中的表达阳性率均高于在癌旁组织中的表达阳性率(P<0.05)。癌组织中MT1-MMP和MMP-2的表达与甲状腺乳头状癌的淋巴结转移相关(P<0.05),MMP-2的表达还与甲状腺乳头状癌的包膜侵犯相关(P<0.05);MT1-MMP和MMP-2在甲状腺乳头状癌组织中的表达呈正相关(r=0.256,P<0.05)。结论 MT1-MMP和MMP-2可能参与了甲状腺乳头状癌的包膜侵犯和淋巴结转移,且MT1-MMP和MMP-2在甲状腺乳头状癌的进展过程中可能发挥协同作用。
Objective To investigate the role of membrane type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in papillary thyroid carcinoma and adjacent tissues. Expression, to explore the significance of its expression in the development of papillary thyroid carcinoma. Methods Immunohistochemical SP method was used to detect the expression of MT1-MMP and MMP-2 in 164 cases of thyroid papillary carcinoma and its adjacent tissues. The relationship between the expression of MT1-MMP and MMP-2 and the clinicopathological features of papillary thyroid carcinoma was analyzed. Results The positive rate of MT1-MMP expression was 11.0% (18/164) in thyroid papillary carcinoma, and the positive rate of MMP-2 was 14.0% (23/164). In thyroid papillary carcinoma, MT1 The positive rates of MMP and MMP2 expression were 61.6% (101/164) and 67.7% (111/164), respectively; the positive rate of MMP-2 and MMP2 in cancer tissues was higher than that in para-carcinoma tissues (P<0.05). <0.05). The expression of MT1-MMP and MMP-2 in cancer tissues was associated with lymph node metastasis of papillary thyroid carcinoma (P<0.05), and the expression of MMP-2 was also associated with capsular invasion of thyroid papillary carcinoma (P<0.05); MT1 There was a positive correlation between the expression of MMP and MMP-2 in papillary thyroid carcinoma (r=0.256, P<0.05). Conclusion MT1-MMP and MMP-2 may be involved in capsular invasion and lymph node metastasis of papillary thyroid carcinoma, and MT1-MMP and MMP-2 may play a synergistic role in the progression of papillary thyroid carcinoma.