癌痛是临床晚期恶性肿瘤患者最常见的症状之一,也是破坏患者生活质量的重要因素。近年来出现的各种骨癌痛模型,为深入研究骨癌痛机制、寻找新的治疗方法提供了契机。骨癌痛具有复杂的发病机制。随着肿瘤的生长和骨质的破坏,病灶中与肿瘤相关的诸多因子不断释放(如前列腺素、内皮素、神经生长因子等),在肿瘤局部构成复杂而独特的微环境,持续激活并敏化支配骨组织的伤害性感受器。在骨癌痛发展的过程中,交互存在着炎症反应、神经损伤及其他组织损伤等病理变化,导致伤害性刺激传入信息增加,引起剧烈的疼痛。 Cancer pain is one of the most common symptoms of patients with advanced clinical malignancies and an important factor in ruining the quality of life of patients. In recent years, a variety of bone cancer pain model appears to provide an opportunity for further study of bone cancer pain mechanism, looking for new treatment methods. Bone cancer pain has a complex pathogenesis. With the growth of tumor and the destruction of bone, many factors associated with tumor in the lesion are continuously released (such as prostaglandin, endothelin, nerve growth factor, etc.), forming a complex and unique microenvironment in the tumor site, Burn the nociceptors that dominate bone tissue. In the process of bone cancer pain development, the interactive existence of inflammation, nerve damage and other tissue damage and other pathological changes, leading to increased information on harmful stimuli, causing severe pain.