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20例曼氏血吸虫病的男性患者(平均年龄23岁;平均虫卵计数429±311个/克粪便),用羟氨喹(Oxamniguine)口服治疗,每人每天20毫克/公斤体重,连续三天。17例有肝脾肿大,内2例有腹水。3例有弥漫性结肠息肉病,其中1例有腹水。除了1例治疗后3天出现轻度呕血以外,其余病人对该药耐受良好。然而11例完成治疗后24～48小时出现持续2～3天的发热,并伴有尿中血吸虫抗原排泄物的增加。完成治疗后3个月,除1例年轻病人外,其余患者在粪便和直肠组织中均未发现有活卵。治疗后6个月,3例患结肠息肉病的病人显示出明显的临床征象的改善,并且乙状结肠镜和钡剂灌肠检查表明所有息肉几乎完全消失。
Twenty males of schistosomiasis (mean age 23 years; mean egg count 429 ± 311 per gram of stool) were treated orally with oxamniguine 20 mg / kg body weight per person per day for three consecutive days . 17 cases of hepatosplenomegaly, ascites in 2 cases. 3 cases had diffuse colon polyposis, 1 case had ascites. The patients were well tolerated except for 1 case of mild vomiting 3 days after treatment. However, 11 patients completed 24 to 48 hours after treatment for 2 to 3 days of fever, accompanied by increased urinary schistosome antigen excretion. Three months after the completion of treatment, except for one case of young patients, none of the other patients found any ovum in the feces and rectum. At 6 months after treatment, 3 patients with colon polyposis showed significant improvement in clinical signs, and sigmoidoscopy and barium enema examination showed almost complete disappearance of all polyps.