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为了解重组人肝再生增强因子 (hALR)对大鼠实验性肝纤维化形成过程中血清透明质酸浓度的影响 ,建立了四氯化碳中毒性及人血白蛋白免疫损伤性两种大鼠肝纤维化模型。在造模的同时给予不同剂量hALR治疗 ,并在不同的时间点留取大鼠血清标本 ,测定透明质酸浓度。结果表明 ,在两种模型中hALR两组大鼠血清透明质酸浓度在造模过程中的不同阶段均明显低于模型组。高剂量hALR组大鼠血清透明质酸浓度均明显低于低剂量组。上述结果提示 ,重组人肝再生增强因子可降低实验性肝纤维化大鼠血清透明质酸含量
To understand the effect of recombinant human augmenter of liver regeneration (hALR) on the concentration of serum hyaluronic acid in the process of experimental hepatic fibrosis in rats, two kinds of rat models of carbon tetrachloride toxicity and human immunoglobulin immunosuppression Liver fibrosis model. Different doses of hALR were given at the same time of modeling, and rat serum samples were taken at different time points to determine the concentration of hyaluronic acid. The results showed that serum hyaluronic acid concentrations in both groups of hALR rats in the two models were significantly lower than those in the model group at different stages in the modeling process. Serum hyaluronic acid concentrations in high dose hALR group were significantly lower than those in low dose group. The above results suggest that recombinant human augmenter of liver regeneration can reduce the serum hyaluronic acid content in experimental hepatic fibrosis rats