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目的:探讨胃蛋白酶原(PG)水平及PGⅠ/PGⅡ的比值在慢性胃病和胃癌中的意义及其诊断价值。方法:将128例胃部疾病患者分为三组:慢性萎缩性胃炎组40例;十二指肠溃疡组43例;胃癌组45例。同时选取38例健康体检者作为对照组。采用时间分辨荧光免疫分析法检测患者血清中PGⅠ、PGⅡ的含量并计算其比值。结果:慢性萎缩性胃炎组和十二指肠溃疡组血清PGⅠ/PGⅡ的比值均低于正常对照组,胃癌组血清PGⅠ/PGⅡ的比值显著低于正常对照组,差异有统计学意义(P<0.01)。结论:PG含量与胃黏膜分泌功能密切相关,血清PGⅠ/PGⅡ的比值对于早期发现和监测胃癌具有重要意义。
Objective: To investigate the significance of pepsinogen (PG) and the ratio of PGⅠ / PGⅡ in chronic gastritis and gastric cancer and its diagnostic value. Methods: 128 cases of gastric diseases were divided into three groups: 40 cases of chronic atrophic gastritis group; 43 cases of duodenal ulcer group; 45 cases of gastric cancer group. At the same time, 38 healthy subjects were selected as the control group. Time-resolved fluorescence immunoassay was used to detect PGI and PGII levels in serum and calculate the ratio. Results: The ratio of serum PGⅠ / PGⅡ in chronic atrophic gastritis group and duodenal ulcer group was lower than that in normal control group. The ratio of serum PGⅠ / PGⅡ in gastric cancer group was significantly lower than that in normal control group (P < 0.01). Conclusion: The content of PG is closely related to the secretion of gastric mucosa. The ratio of serum PGⅠ / PGⅡ is of great significance for the early detection and monitoring of gastric cancer.