纺锤体检查点阻滞细胞进入分裂后期直到所有染色体着丝点正确与微管联接 ,确保染色体均等分配 ,维持基因组稳定性。纺锤体检查点的分子调控机制已初步建立。许多肿瘤细胞存在纺锤体检查点功能缺陷 ,但纺锤体检查点基因突变异常罕见 ,需要深入了解肿瘤纺锤体检查点调控机制 ,为肿瘤防治提供新的有效策略 Spindle checkpoints block cells from entering the late division until all of the chromosome centromere links correctly with the microtubules, assuring equal distribution of chromosomes and maintaining genome stability. Spindle checkpoint molecular regulation mechanism has been initially established. Many tumor cells have spindle checkpoint dysfunction, but spindle checkpoint gene mutation is extremely rare, which needs deep understanding of tumor spindle checkpoint regulation mechanism, providing new and effective strategies for tumor prevention and treatment