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1964年,McGoVern首先注意到微小病变型肾病综合征形态学转化的现象,在39例病人中,6年后再次活检发现9例已演化成局灶节段性肾小球硬化。近5年来,美国Downstate医疗中心儿科肾病组对一些经常复发的肾病综合征患儿进行了系统观察。按照以往描述的微小病变、IgM肾病和局灶节段性硬化的定义,对48例最初为微小病变的患儿进行了至少5年的随访。 48例患儿的起病年龄平均4.1(11月～16岁)岁,随访时间平均11.2(5～18)年。患儿第1次活检
In 1964, McGoVern first noticed the morphological transformation of minimal-neovascular nephrotic syndrome. In 39 patients, re-biopsy 6 years later found that 9 had developed focal segmental glomerulosclerosis. In the past five years, the Pediatric Nephrology Group at the Downstate Medical Center in the United States systematically observed some patients with recurrent nephrotic syndrome. Forty-eight children with minimal lesions were followed for at least 5 years following the previously described definition of minimal change, IgM nephropathy and focal segmental sclerosis. The mean age of onset in 48 children was 4.1 years (ranged from 11 months to 16 years), with an average follow-up of 11.2 (5-18) years. The first biopsy in children