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目的观察医院鲍曼不动杆菌的耐药性，分析其与抗药药物使用情况的相关性。方法收集2009年1月~2011年12月扬州市江都人民医院住院患者的痰液、血液、尿液等送检标本中分离的鲍曼不动杆菌，采用 K-B 纸片扩散法进行药敏试验，从医院抗菌药物监测网数据库查取相关药物的使用情况，计算抗菌药物使用强度(AUD)，采用 Pearson 相关法分析耐药率与 AUD 的相关性。结果从2009年~2011年鲍曼不动杆菌对常用抗菌药物的耐药率普遍呈上升趋势，其对头孢呋辛钠的耐药率最高，其次为环丙沙星、哌拉西林钠/他唑巴坦钠。头孢他啶、美罗培南、亚胺培南的药物 AUD 与耐药率之间有正相关性(r=0.871，=0.024；r=0.897，P=0.015；r=0.993，=0.000)。结论抗菌药物使用情况与耐药率之间存在一定相关性，临床合理用药可在一定程度上降低耐药率。“,”Objective To observe the drug resistance of acinetobacter baumannii and its correlation with antibiotics use. Methods Acinetobacter baumannii were isolated from specimen of sputum, blood and urine of inpatients between Jan. 2009 to Dec. 2011. Drug sensitive test were performed by disc diffusion test (k-b). Data of antibiotics use in hospital Drug monitoring database were collected for calculating AUD. The relationship between drug resistance of acinetobacter baumannii and AUD were analysied by Pearson methods. Results The drug resistance rate of acinetobacter baumannii was increased between 2009 and 2011, in which resistance rate to cefuroxime Sodium ranked the top, followed by ciprofloxacin, piperacillin sodium/ tazobactam sodium. There were correlation between resistance of acinetobacter baumannii and AUD of ceftazidime ( =0.871, =0.024), meropenem ( =0.897,=0.015) and imipenem (r=0.993,P=0.000). Conclusion Drug resistance of acinetobacter baumannii is associated with increased use of antibiotics, which can be regulated by rational clinical medication.