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青酶胺(PCA)治疗类风湿关节炎(RA)时,疗效与红细胞内谷胱甘肽(E-GSH)浓度间的关系。硫三肽谷胱甘肽(GSH)是细胞内除了蛋白质-SH之外的-SH最重要来源。在细胞内约20～30%的GSH以和蛋白质结合的形式存在。作者在用PCA治疗RA病人前和治疗期间,测定了95例患者的E-GSH浓度(应用酶测定法)。结果发现其值于疾病稳定期显著恒定;在高度活动期则下降而于缓解期升高(正常对照值为2.2±0.5μmol/L)。作者测定18例用PCA治疗前和治疗1周或1月的RA病人的E-GSH浓度,12例在治疗后2～3月E-GSH逐渐升高,3个月后其中7例临床明显缓解,5例轻度好转(其中2例随访少于2个月)。通常,E-GSH浓度于应用PCA治疗后2～8周内升高,远远早于临床症状缓解。其他6例临床无效者,在治疗最初4～6周内E-GSH不升高或仅轻度升高,其中4例以及另
The relationship between curative effect and glutathione (E-GSH) concentration in erythrocytes during treatment of rheumatoid arthritis (RA) with green enzyme (PCA). Thiotripipeptide glutathione (GSH) is the most important source of -SH in cells other than the protein-SH. Approximately 20-30% of the GSH in the cell is in the form of protein bound. The authors measured the E-GSH concentrations in 95 patients (using enzyme assays) before and during the treatment of RA patients with PCA. The results showed that the value was significantly constant in the stable period of the disease, decreased in the high activity period and increased in the remission period (normal control value was 2.2 ± 0.5 μmol / L). E-GSH concentrations were measured in 18 patients with RA prior to and 1 week or 1 month of treatment with PCA. E-GSH levels were gradually increased in 12 patients between February and March after treatment, and 7 of 3 patients were significantly relieved after 3 months , 5 cases were mild improvement (2 cases were followed up for less than 2 months). Normally, E-GSH levels rise within 2 to 8 weeks after PCA treatment, well before the onset of clinical symptoms. The other 6 cases of clinical ineffective, in the first 4 to 6 weeks of treatment E-GSH does not increase or only slightly elevated, of which 4 cases and the other