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目的探讨家兔失血性休克过程中唇香草对脑的保护作用及其可能的作用机制。方法健康家兔32只,随机分为对照组、失血性休克组、补液组和唇香草组,每组8只。在规定时间点测定脑组织中琥珀酸脱氢酶(SDH)、ATP酶、一氧化氮(NO)、丙二醛(MDA)、髓过氧化物酶(MPO)的变化。结果在失血性休克过程中,脑组织SDH、ATP酶的活性在休克组和补液组与对照组比较差异有统计学意义(P<0.05),经唇香草治疗后其活性与对照组比较差异无统计学意义(P>0.05)。而休克组和补液组的NO、MDA及MPO的含量增加,与对照组比较差异有统计学意义(P<0.05),但在唇香草组含量均明显减少(P>0.05)。结论唇香草对失血性休克时脑组织的损伤有一定的保护作用。
Objective To investigate the protective effect of Labloss vanilla on brain during hemorrhagic shock in rabbits and its possible mechanism. Methods Thirty-two healthy rabbits were randomly divided into control group, hemorrhagic shock group, rehydration group and lip vanilla group, 8 in each group. The changes in succinate dehydrogenase (SDH), ATPase, nitric oxide (NO), malondialdehyde (MDA), and myeloperoxidase (MPO) in the brain tissue were measured at predetermined time points. Results During hemorrhagic shock, the activity of SDH and ATPase in brain tissue was significantly different between the shock group and the rehydration group compared with the control group (P<0.05). Statistical significance (P>0.05). The levels of NO, MDA, and MPO in the shock group and the rehydration group increased compared with the control group (P<0.05), but the content in the lip vanilla group decreased significantly (P>0.05). Conclusion Herbal lip has a protective effect on brain tissue damage in hemorrhagic shock.