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目的:探讨跨膜型TNF-α与磷酸化NF-κB在三阴性乳腺癌(TNBC)中的表达及其临床意义。方法:采用免疫组化法检测52例三阴性乳腺癌与30例非三阴性乳腺癌组织中跨膜型TNF-α与磷酸化NF-κB的表达,并分析其与三阴性乳腺癌各临床指标的相关性。结果:跨膜型TNF-a与磷酸化NF-κB在三阴性乳腺癌中的阳性表达率分别为82.7%(43/52)和67.3%(35/52),均显著高于非三阴性乳腺癌,差异具有统计学意义(P<0.05)。在三阴性乳腺癌中,跨膜型TNF-α及磷酸化NF-κB的表达与肿瘤大小和淋巴结转移与否显著相关(P<0.05),且跨膜型TNF-α与磷酸化NF-κB的表达呈显著正相关(P<0.05)。结论:跨膜型TNF-α及磷酸化NF-κB高表达可能预示着TNBC更差的化疗敏感性和预后,有望成为TNBC预后的重要预测因子。跨膜型TNF-α通过激活磷酸化NF-κB激活其下游的抗凋亡和促增殖因子,与三阴性乳腺癌的发生发展有关。
Objective: To investigate the expression of transmembrane-type TNF-α and phosphorylated NF-κB in triple negative breast cancer (TNBC) and its clinical significance. Methods: The expressions of transmembrane-type TNF-α and phosphorylated NF-κB in 52 cases of triple-negative breast cancer and 30 cases of non-triple-negative breast cancer were detected by immunohistochemistry. The expressions of TNF-α and phosphorylated NF- Relevance. Results: The positive rates of transmembrane TNF-α and phosphorylated NF-κB in triple negative breast cancer were 82.7% (43/52) and 67.3% (35/52), respectively, which were significantly higher than those in non-triple negative breast Cancer, the difference was statistically significant (P <0.05). In triple-negative breast cancer, the expression of transmembrane TNF-α and phosphorylated NF-κB was significantly correlated with tumor size and lymph node metastasis (P <0.05), and transmembrane TNF-α and phosphorylated NF-κB There was a significant positive correlation (P <0.05). Conclusion: The high expression of transmembrane TNF-α and phosphorylated NF-κB may predict the worse chemosensitivity and prognosis of TNBC, which is expected to be an important predictor of TNBC prognosis. Transmembrane TNF-α activates its downstream anti-apoptotic and pro-proliferative factors by activating phosphorylation of NF-κB, which is associated with the development of triple negative breast cancer.