论文部分内容阅读
采用抗T淋巴细胞单克隆抗体(T_3、T_4、及 T_)及PAP技术对19例(21例次)SLE患者皮损中T淋巴细胞亚群进行了检测。结果表明:活动期与非活动期 SLE 患者皮损中 T 细胞各亚群均较对照组明显增高,T_4/T_比值降低,有显著性意义;同一组织中,与 T_4~+细胞相比,多显示 T_~+占优势;除真皮层外,T_~+细胞还浸润至表皮层。提示 SLE 皮肤损害与局部 T 淋巴细胞浸润有着一定的关系。本观察还发现,活动期与非活动期患者相比,皮损中 T 淋巴细胞各亚群及 T_4/T_比值均无显著性差异,推测皮损中炎性细胞浸润的程度与全身病情轻重关系不大,而与皮肤损害程度有关。
T lymphocyte subsets in lesions of 19 patients with SLE (21 cases) were detected by anti-T lymphocyte monoclonal antibodies (T_3, T_4, T_) and PAP. The results showed that: T lymphocyte subsets in the active and inactive SLE patients were significantly higher than those in the control group, and the T 4 / T_ ratio was decreased, with significant significance; in the same tissue, compared with T 4 + cells, Multi-display T_ ~ + dominant; in addition to the dermis, T_ ~ + cells also infiltrated the epidermis. Tip SLE skin lesions and local T lymphocyte infiltration has a certain relationship. The observation also found that active and inactive patients compared to skin lesions in T lymphocyte subsets and T_4 / T_ ratio was no significant difference, speculated that the extent of inflammatory cell infiltration in skin lesions and severity of the disease Little relationship, but with the degree of skin damage.