目的:为下丘脑室旁核参与惊厥应答提供形态学资料.方法:以听源性惊厥易感大鼠为动物模型,用免疫组织化学ABC法显示下丘脑室旁核神经元即早基因c-fos的表达.结果:惊厥发作鼠室旁核神经元,尤其是小细胞亚核神经元c-fos表达显著增加.结论:下丘脑室旁核神经元在惊厥状态下处于活动状态,参与了惊厥应答. OBJECTIVE: To provide morphological data for the hypothalamic paraventricular nucleus to participate in the convulsion response.Methods: The animal model of auditory convulsive susceptibility was used as an animal model, immunohistochemical ABC method was used to show the neurons of hypothalamic paraventricular nucleus, ie, the early gene c- fos expression.Results: The c-fos expression of paraventricular nucleus neurons, especially small subnuclear neurons increased significantly in seizures.Conclusion: The neurons in hypothalamic paraventricular nucleus are active in convulsions and participate in the convulsion answer.