Marks等(1956)与Conning等(1971)指出粉尘对巨噬细胞的毒作用同它在动物体内产生的纤维化的程度直接相关,但未说明尘粒大小与结构的影响。本文作者用大鼠腹膜与肺泡巨噬细胞悬液(10~6细胞/毫升)与23种矿石或聚合物粉末悬液(150毫克/毫升)在一起孵育2小 Marks et al. (1956) and Conning et al. (1971) pointed out that the toxic effects of dust on macrophages are directly related to the degree of fibrosis that they produce in animals, but the effects of dust particle size and structure are not explained. The authors incubated rat peritoneal and alveolar macrophage suspensions (10-6 cells / ml) with 23 ore or polymer powder suspensions (150 mg / ml) for 2 hours