论文部分内容阅读
Lissauer(1865)以亚砷酸鈉治疗慢性白血病是用結构明确的純化合物临床治疗肿瘤的先声。Herrold(1941)以雌性素作前列腺癌治疗。1942年Gilman和Willkison等分别考虑到氮芥对骨髓抑制作用进行了氮芥类化合物治疗造血系統肿瘤的尝試。Farber(1948)以抗叶酸物治疗小儿急性白血病获得暫时緩解;Hackmann(1953)及Schulte(1953)发現放綫菌素丙对淋巴肉芽肿有疗效。此种成就成为目前寻找抗肿瘤药物的背景,从此,后继者不断从生物烃化剂,抗代谢物、激素、抗菌素中探索有效的抗肿瘤药物。
Lissauer (1865) treated with sodium arsenite for chronic leukemia was a precursor to clinical treatment of tumors with well-defined pure compounds. Herrold (1941) treats estrogen as prostate cancer. In 1942, Gilman and Willkison considered the effect of nitrogen mustard on myelosuppression to treat hematopoietic tumors with nitrogen mustard compounds. Farber (1948) obtained temporary relief from anti-folic acid therapy in children with acute leukemia; Hackmann (1953) and Schulte (1953) found that actinomycin C was effective in lymphogranuloma. Such achievements have become the background for the search for anti-tumor drugs. Since then, the successors have been exploring effective anti-tumor drugs from bio-alkylating agents, antimetabolites, hormones, and antibiotics.