论文部分内容阅读
核受体是人体中含量最丰富的转录因子之一,通过与相应的配体及其辅助调节因子相互作用,调控基因的表达,从而在机体的生长发育、新陈代谢、细胞分化、细胞内环境的稳定及体内许多生理过程中发挥重要作用.很多疾病的发生和发展都与核受体有着直接或间接的联系,这也是核受体受到广泛关注的原因.近年来大量的研究发现核受体产生的作用贯穿于眼球的发育、角膜病、白内障、青光眼、年龄相关性黄斑变性、视网膜色素变性、视网膜新生血管病变、眼科肿瘤等眼科疾病的发生和发展.值得注意的是,某些难治性疾病,特别是糖尿病和某些癌症,如前列腺癌和乳腺癌中已有核受体相关靶点药物进入临床,其研究前景可见一斑.相信不断发现相关核受体与眼科疾病的关系能更好地理解疾病的发展过程,利于疾病的诊断与鉴别诊断,也能在治疗上带来新的启发,使靶向治疗成为现实,甚至让个体化用药成为可能.本文主要就核受体的基本背景及其与眼科疾病的关系进行综述.“,”Nuclear receptor is one of abundant transcription factors in human body.Interacted with corresponding ligands,coactivators and corepressors,nuclear receptor can regulate the expression of genes and plays important roles in the development,cell differentiation,physiological and metabolic processes.Many diseases are directly or indirectly linked to nuclear receptor,which is the reason why nuclear receptor has recently attracted widespread attention.In recent years,a large number of studies have found that the abnormal expression of nuclear receptor is associated with a variety of ocular diseases.It is worth noting that nuclear receptor related target drugs in some refractory diseases,especially diabetes and some cancers such as prostate cancer and breast cancer have be used in clinic.It is not difficult to see the prospect of nuclear receptors.Continual exploration of the relationship between nuclear receptors and ocular diseases not only has an important significance in the study of the occurrence and development of diseases,but also brings new inspiration in the treatment.These studies make target therapy become a reality,and even make individualized medication possible.This article mainly reviewed the basic background knowledge of nuclear receptor and the relationship between nuclear receptor and ocular diseases.