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采用正交实验 ,以提取次数、加乙醇量、乙醇浓度、提取时间为考察因素 ,黄连总生物碱含量为考察指标 ;以提取次数、提取时间、加水量、药材粒度为考察因素 ,甘草次酸含量为考察指标 ,分别优选了胃舒胶囊制备过程中醇提和水提的工艺条件。结果 ,醇提工艺为用 8倍量的 70 %乙醇提取 2次 ,每次 2h ;水提工艺为加 9倍量的水 ,提取 2次 ,两次 2h ,药材粒度为 3～ 1 0mm颗粒
Orthogonal experiments were used to determine the number of extractions, the amount of ethanol added, the concentration of ethanol, and the extraction time. The total alkaloids content of Coptis chinensis was used as the inspection index, and the extraction times, extraction time, water addition, and particle size of the medicinal materials were used as the inspection factors to determine glycyrrhetinic acid. The content is the inspection index, which respectively optimizes the process conditions of alcohol extraction and water extraction during the preparation of Weishu Capsule. The result was that the alcohol extraction process used 8 times 70% ethanol to extract 2 times, 2 hours each time; the water extraction process added 9 times of water, extracted 2 times, twice for 2 hours, and the medicine particle size was 3 to 10 mm.