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自从1946年Ｂａｌｅｓ开创性地研究社会心理应激与成瘾物质滥用的关系,至今50余年,无论是基于人群的临床流行病学研究,还是动物实验,均证明应激与成瘾及复吸间存在着肯定的正相关关系[1]。动物自身给药(ＳＡ)模型及动物ＳＡ复发模型的建立更是极大地推动了应激与成瘾关系?..
Since Bales’ groundbreaking study of the relationship between psychosocial stress and substance abuse in 1946, over 50 years now, both population-based clinical epidemiology and animal experiments have demonstrated that stress and addiction and relapsing There is a positive positive correlation [1]. The establishment of animal self-administration (SA) model and animal SA recurrence model greatly promoted the relationship between stress and addiction.