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目的:探析肺癌患者的早期诊断中多种肿瘤标志物和肺部影像学联合检测的临床意义。方法:分析在我院接受治疗的150例肺癌患者的临床资料,选取同期在我院就诊的70例良性疾病患者作为本次实验的肺良性病组,另外选取同期来院体检的52例健康体检者作为本次研究的对照组。比较三组患者的5种肿瘤标志物的检测结果、血清肿瘤标志物的敏感度和特异度以及各项指标联合检测敏感度。结果:肺癌组患者的血清NSE、CEA及CYFRA21-1的水平均比肺良性病组和对照组患者高,肺癌组的SCC值比对照组高。各肿瘤标志物的特异度均较高;CEA的敏感度(63.8%)最高,其次是CYFRA21-1(44.1%);CEA的阴性、阳性预测值均最高,分别是76.6%、75.0%。CEA+SCC+CYFRA21-1+NSE+影像学联合检测的误诊率最低,为0.82%。结论:肿瘤标志物和肺部影像学的联合检测在早期诊断肺癌中有着极其重要的临床意义,可以显著降低误诊率。
Objective: To explore the clinical significance of multiple tumor markers and pulmonary imaging in the early diagnosis of lung cancer patients. Methods: The clinical data of 150 patients with lung cancer who were treated in our hospital were analyzed. Seventy patients with benign disease who were treated in our hospital during the same period were selected as the benign lung disease group. In addition, 52 healthy subjects As the control group of this study. The test results of five tumor markers, the sensitivity and specificity of serum tumor markers and the joint detection sensitivity of three indicators were compared. Results: The levels of serum NSE, CEA and CYFRA21-1 in patients with lung cancer were higher than those in patients with benign lung disease and controls. The SCC in lung cancer patients was higher than that in controls. The sensitivity of CEA was the highest (63.8%), followed by CYFRA21-1 (44.1%). The negative predictive value of CEA was the highest (76.6% and 75.0%, respectively). The lowest misdiagnosis rate of CEA + SCC + CYFRA21-1 + NSE + imaging was 0.82%. Conclusion: The combined detection of tumor markers and pulmonary imaging has an extremely important clinical significance in the early diagnosis of lung cancer, which can significantly reduce the rate of misdiagnosis.