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为观察棉酸对人类睾丸精子发生作用的长期效应以及探索部分服药者停药后精子难以回升的机理,对19例服棉酸者(总剂量1,960mg-14,475mg)在停药后不同时间(最长者停药60个月)作睾丸活检,进行组织学及超微结构观察。光镜下,根据精子发生的障碍性质与程度可将病变分为三种类型:紊乱型、落脱型及严重障碍型。电镜下,主要描述了生精细胞发育不同步的独特现象,也观察了支持细胞与间质细胞的形态改变。结果表明:服药剂量及停药时间与生精障碍的程度之间并无明确的平行关系。形态学观察提示,服棉酚后可能引起对精子抗原的自身免疫反应,这可能是部分服药者停药后精子难以回升的原因之一。
In order to observe the long-term effect of cotton acid on human testicular spermatogenesis and to explore the mechanism of some patients taking sachet difficult to recover after stopping drug treatment, 19 patients taking on sialic acid (total dose 1,960mg-14,475mg) The longest withdrawal 60 months) for testicular biopsy, histological and ultrastructural observation. Light microscope, according to the nature and extent of spermatogenesis disorders can be divided into three types of lesions: disorganized, off-type and severe disability. Under the electron microscope, the unique phenomenon that the spermatogenesis is not synchronized is mainly described, and the morphological changes of the supporting cells and interstitial cells are also observed. The results showed that there was no clear parallel relationship between dosage and withdrawal time and the degree of dysbiosis. Morphological observation suggests that gossypol may cause autoimmune response to sperm antigens, which may be one of the reasons why sperm are difficult to recover after some patients take medicine.