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近年来,对血管内皮细胞舒血管因子(EDRF)已有研究,内毒素(LPS)可使其大量释放。本文用SD麻醉鼠、显微录像提睾肌微血管,并连续记录平均动脉压(MAP)。实验分①:LPS组(15mg/kg iv n=5):第4分钟MAP降至12.39±1.15kpa,P<0.05,后略回升。提睾肌微动脉(6～27μm)在3分后舒张1.1—1.7μm P<0.05。②注LPS 3分后给L—N—精氨酸(LNMA为EDRF合成抑制剂,15mg/kg iv n=5)在第8～10分钟MAP升至18.35±7.26kpa,P<0.05、提睾肌微动脉在第6分缩2.5μm,P<0.05,7～10分缩4.5—6.6μm,P<0.01。表明EDRF
In recent years, vascular endothelial cell vasodilator factor (EDRF) has been studied, and endotoxin (LPS) can release a large amount of it. In this study, mice were anesthetized with SD and microscopic videos of cremaster muscle microvessels. Mean arterial pressure (MAP) was continuously recorded. The experiment was divided into 1: LPS group (15 mg/kg iv n=5): MAP dropped to 12.39±1.15 kpa at 4 minutes, P<0.05, and then slightly increased. The cremaster arterioles (6-27 μm) had a relaxation of 1.1-1.7 μm at 3 minutes P<0.05. 2 LPS-N-arginine (LNMA for EDRF synthesis inhibitor, 15 mg/kg iv n=5) was given after LPS 3 minutes, MAP increased to 18.35±7.26 kpa at 8th to 10th minute, P<0.05, creatinine The number of muscle arterioles at the 6th minute contraction was 2.5μm, P<0.05, 7～10 minutes contraction was 4.5-6.6μm, P<0.01. Indicates EDRF