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大豆异黄酮是一类具有多种生物活性的天然植物雌激素,主要包括染料木素、大豆黄素及少量黄豆素。近年来的研究表明,大豆异黄酮可能会在某些敏感的生命期内引起潜在的毒性作用。本文着重从流行病学和动物实验两方面对大豆异黄酮的致癌性、生殖内分泌毒性、与其它物质联合暴露的毒性及其它毒性作用(如免疫毒性、细胞毒性、遗传毒性等)进行简要概述,以便对大豆异黄酮的健康效应有一较全面的了解。
Soy isoflavones are a class of natural phytoestrogens with a variety of biological activity, including genistein, daidzein and a small amount of soyin. Recent studies show that soy isoflavones may cause potential toxic effects during some sensitive lifetimes. This article focuses on the epidemiological and animal experiments from two aspects of soy isoflavones carcinogenicity, reproductive and endocrine toxicity, combined with other substances exposed toxicity and other toxicological effects (such as immunotoxicity, cytotoxicity, genotoxicity, etc.) In order to have a more comprehensive understanding of the health effects of soy isoflavones.