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作者讨论一例脉络膜恶性黑瘤行光化学疗法的结果:患者女,38岁,左眼黄斑部颞侧可见一黑色的大肿块,表面有出血,诊断为脉络膜恶性黑瘤。静脉注射血卟啉衍化物(HPD)2.5mg/kg,2～3日后用氩激光照射(使用Y500滤器),条件是2000μm、200mW,2天后在9个部位共照射57分钟,3天后在4个部位共照射24分钟。因肿瘤没有缩小的趋势而行眼球摘除术。病理诊断为脉络膜恶性黑瘤,从肿瘤表面到约1mm的深处见由于光化学疗法所致的肿瘤细胞的崩溃坏死,但比1mm更深处无效应。
The authors discuss the results of a choroidal malignant melanoma treated with photochemotherapy: A 38-year-old woman with a large, black mass on the temporal side of the macular area of the left eye showed hemorrhage on the surface and was diagnosed as choroidal malignant melanoma. 2.5 mg / kg of hematoporphyrin derivative (HPD) was intravenously injected and irradiated with argon laser (using a Y500 filter) after 2 to 3 days under the conditions of 2000 μm and 200 mW. After 2 days, co-irradiation was performed at 9 sites for 57 minutes. A total of 24 minutes exposure to a site. Because of the trend of tumor shrinking without enucleation. Pathological diagnosis of choroidal malignant melanoma, from the tumor surface to the depth of about 1mm due to photochemical therapy due to tumor necrosis, but no effect deeper than 1mm.