琥珀酸是较普遍存在于自然界的有机酸,主要具有抗惊厥、镇静、降低体温及镇痛等中枢抑制作用,毒性很小。由于琥珀酸的化学结构与脑内主要抑制性递质γ-氨基丁酸相似,且两者通过脑内独有的葡萄糖代谢旁路发生密切联系,因此本文还讨论了琥珀酸的中枢作用与脑内γ-氨基丁酸水平之间的关系。 Succinic acid is a more common organic acid in nature, mainly with anticonvulsant, sedation, lower body temperature and analgesic and other central inhibitory effect, little toxicity. Since the chemical structure of succinic acid is similar to γ-aminobutyric acid, the major inhibitory neurotransmitter in the brain, and both are closely linked via a unique glucose metabolism pathway in the brain, the central role of succinate in brain Γ-aminobutyric acid levels within the relationship between.