On the basis of general situation and new characteristics of tobacco mosaic virus (TMV) in Wuxi tobacco area in 2011, the paper expounded the objective reasons of TMV via systemic investigation, field experiment and date sorting. Meanwhile, combined with meteorological conditions and results of systemic investigation, the study especially analyzed meteorological conditions, outbreak and prevalence regularity of TMV and control efficacy of chemical reagents against TMV. The results showed that climatic conditions were the main conditions affecting TMV. There were three occurrence peaks of TMV in 2011, as a result of meteorological conditions of the months from April to June. The peaks were concerned with a wide range of rainfall about half a month before, low temperature, high humidity and scant sunshine and temperature jump after rain. The results of control effects showed that the chemical reagents could obviously prevent TMV, but once tobacco plants were infected, spraying chemical reagents would not have effective control effect against TMV. On the basis of general situation and new characteristics of tobacco mosaic virus (TMV) in Wuxi tobacco area in 2011, the paper expounded the objective reasons of TMV via systemic investigation, field experiment and date sorting. Meanwhile, combined with meteorological conditions and results of systemic investigation, the study particularly analyzed meteorological conditions, outbreak and prevalence regularity of TMV and control efficacy of chemical reagents against TMV. There are three occurrence peaks of TMV in 2011, as a result of meteorological conditions of the months from April to June. The peaks were concerned with a wide range of rainfall about half a month before, low temperature, high humidity and scant sunshine and temperature jump after rain. The results of control effects showed that the chemical reagents couldizations prevent TMV, but once tobacco plants were infected, spraying chemical r eagents would not have effective control effect against TMV.