本文对15例急性戊型病毒性肝炎患者血清中β2－M、性激素和血清生化指标进行了检测并与健康人进行比较，检测结果表明：戊型肝炎患者血清中β2－M、LH、E2的含量显著高于健康人（P＜0.01）；T的含量与健康人比较无显著差异（P＞0.05）。肝功检测TBIL、DBIL、ALP、GGT、LCDH、AST、ALT均显著高于健康人（P＜0．01），而CHE显著低于健康人（P＜0．05）。实验证明，戊型肝炎病毒不但损害肝功亦影响β2－M和性激素的代谢。 In this paper, serum β2-M, sex hormone and serum biochemical indexes of 15 patients with acute viral hepatitis were detected and compared with healthy people. The results showed that β2-M, LH, E2 (P <0.01). The content of T had no significant difference with that of healthy people (P> 0.05). The serum levels of TBIL, DBIL, ALP, GGT, LCDH, AST and ALT in liver function test were significantly higher than those in healthy people (P <0.01), while those in CHE were significantly lower than those in healthy people (P <0.05). Experiments show that hepatitis E virus not only affects liver function but also affect β2-M and sex hormone metabolism.