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喹诺酮类抗菌药(QNs)在60年代已广泛用于许多细菌性感染的治疗。80年代以来氟喹诺酮类抗菌药的发展,上市不少抗菌活性强、药代动力学性质较优的新品种,如诺氟沙星(1978)、培氟沙星(1979)、依诺沙星(1980)、氧氟沙星(1981)、环丙沙星(1982)、洛美沙星(1986)、妥舒沙星(1991)、氟罗沙星(1992)和卢氟沙星(1992)。一般认为QNs具有高效、广谱、低毒、易耐受、使用方便、与常用抗菌药无交叉耐药性和价格比疗效相当的抗生素低廉等优点,因此深受临床欢迎。近年来QNs的销售额平均年增长率达30%,预计到1995年这类抗菌药的销售额将达30亿美元以上,将取
Quinolone antibiotics (QNs) have been widely used in the 1960s for the treatment of many bacterial infections. Fluoroquinolone antibacterials since the 1980s, the listing of many antibacterial activity, better pharmacokinetic properties of new varieties, such as norfloxacin (1978), pefloxacin (1979), enoxacin (1980), ofloxacin (1981), ciprofloxacin (1982), lomefloxacin (1986), tosufloxacin (1991), fleroxacin (1992) and lofloxacin (1992). Generally believed that QNs with high efficiency, broad-spectrum, low toxicity, easy to tolerate, easy to use, no cross-resistance with commonly used antimicrobial drugs and the price is relatively low antibiotic efficacy and so on, so by clinical welcome. In recent years, QNs sales average annual growth rate of 30%, is expected to 1995 sales of these antibacterials will reach 3 billion US dollars, will take