一、引言精子从产生到成熟,是一个漫长而复杂的过程,其中精子的运动是一个令人感兴趣的问题。早在70多年前Tourade首次提出哺乳动物精子在附睾内移行过程中成熟并获得前向运动能力。以后,大量实验都证实了这一论点。对附睾的分段研究,发现附睾头部精子或者静止不动,或者原地转圈、扭动,但无前向运动;而尾部精子在稀释液中则有较强的前向运动。迄今为止,精子从静止状态到获得运动能力这一成熟过程的生化基础是什么,还有许多争议。二、cAMP与精子成熟及运动的关系 60年代末,人们开始重视ATP、cAMP及其有关的一系列酶在精子成熟过程中的作用,特别是在附睾微环境中,这些因素对精子 First, the introduction of sperm from birth to maturity, is a long and complex process, of which the movement of sperm is an interesting issue. As early as 70 years ago, Tourade first proposed that mammalian sperm mature and gain forward motility during epididymal migration. After a large number of experiments have confirmed this argument. Segment of the epididymis study found sperm in the head of the epididymis or stationary, or circling in situ, twisting, but no forward movement; while the tail sperm in the diluent has a strong forward movement. So far, there has been much controversy over what the biochemical basis of the maturation process of sperm from rest to exercise capacity. Second, the relationship between cAMP and sperm maturation and exercise The late 60s, people began to attach importance to ATP, cAMP and its related enzymes in sperm maturation process, especially in the epididymis microenvironment, these factors on sperm