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目的 观察静注小剂量氢吗啡酮对腹腔镜子宫肌瘤切除术患者全麻后寒战的预防作用及安全性.方法 选择ASA Ⅰ ～Ⅱ级,年龄27 ～ 52岁,全麻下行腹腔镜子宫肌瘤切除术的患者60例,随机分为对照(C)组和氢吗啡酮(H)组,每组30例.手术结束前30 min,C组予生理盐水5 mL,iv;H组予氢吗啡酮4μg· kg-(稀释至5 mL),iv.记录麻醉前后不同时间点鼓膜温度,计算术后寒战的发生率,同时记录不良反应的发生情况.结果 2组患者鼓膜温度从诱导后至拔管后30 min均比基础值显著降低,两组间鼓膜温度差异无统计学意义.H组的寒战发生率(13.3％)显著低于C组(46.7％)(P＜0.05),而不良反应发生率2组间差异无统计学意义.结论 静注小剂量氢吗啡酮能安全有效地预防腹腔镜子宫肌瘤切除术患者全麻后寒战的发生.“,”AIM To evaluate the prophylactic effects and safety of intravenous low dose of hydromorphone on postoperative shivering after general anesthesia.METHODS Totally 60 patients with ASA Ⅰ-Ⅱ,aged from 27 to 52 years old,scheduled for elective laparoscopic myomectomy under general anesthesia were divided into group C and group H randomly,each group of 30 patients.Group H received hydromorphone 4 μg · kg-1 (diluted to 5 mL),while group C received saline 5 mL intravenously 30 min before the end of surgery.Tympanic temperatures were determined at different times before and after anesthesia.The incidence of shivering and adverse drug reactions were recorded during postoperative period.RESULTS Tympanic temperatures decreased significantly in both groups compared to the baseline from the end of induction to 30 min after extubation,but there were no significant differences in tympanic temperatures between the 2 groups.The incidence of shivering was reduced greatly in group H (13.3％)compared to group C(46.7％)(P ＜0.05).The difference of incidence of adverse drug reactions between the 2 groups were not significant.CONCLUSION Intravenous injection of low dose of hydromorphone can safely and effectively prevent the occurrence of shivering in patients undergoing laparoscopic myomectomy surgery