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4例早产极低体重儿(1对女性双胞胎,胎龄31周;1对男性双胞胎,胎龄29周)于出生后22～31 d应用利奈唑胺10 mg/kg、1次/8 h静脉泵入抗感染治疗。其中例1、2为单独用药,例3同时联用利奈唑胺、美罗培南及两性霉素B脂质体,例4同时联用利奈唑胺和两性霉素B脂质体。分别于用药后4、16、8和10 d出现血小板计数下降,最低分别为27×10~9/L、74×10~9/L、23×10~9/L、4×10~9/L。停用利奈唑胺并给予对症治疗,6～17 d后血小板计数恢复正常。
4 cases of preterm low birth weight infants (1 pair of female twins, gestational age 31 weeks; 1 pair of male twins, gestational age 29 weeks) 22 to 31 days after birth, linezolid 10 mg / kg, 1/8 h vein Pump anti-infective therapy. Example 1, 2 for the drug alone, Example 3 combined with linezolid, meropenem and amphotericin B liposomes, Example 4 combined with linezolid and amphotericin B liposomes. The platelet counts decreased at 4, 16, 8 and 10 d after treatment, respectively, with the lowest values being 27 × 10 ~ 9 / L, 74 × 10 ~ 9 / L, 23 × 10 ~ 9 / L and 4 × 10 ~ 9 / L. Linezolid was discontinued and symptomatic treatment was given. Platelet counts returned to normal after 6 to 17 days.