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本实验采用PKC抑制剂Staurosporine作用于SACC-83系,观察对P21ras、c-myc表达的影响.结果表明,Stauroporine可明显降低H-ras、c-myc表达程度(p<0.01),这提示PKC对ras、c-myc基因表达具有调控作用,PKC抑制剂可能通过调控癌基因的表达来表现抗肿瘤作用的.
In this study, PKC inhibitor Staurosporine was used to act on SACC-83 line to observe the effect on the expression of P21ras and c-myc. The results showed that Stauroporine can significantly reduce the expression of H-ras and c-myc (p<0.01), suggesting that PKC regulates the expression of ras and c-myc genes. PKC inhibitors may regulate oncogene expression. Performance of anti-tumor effect.