利用体外模拟循环管路和远达效应动物模型，观察致伤瞬间流体扰动和创伤血清对培养的猪主动脉内皮细胞（ＶＥＣ）的作用特点，探讨这两种致伤因素在损伤ＶＥＣ过程中的关系。发现高速投射物所致流体扰动可使ＶＥＣ的结构和功能发生明显改变。表现为ＶＥＣ膜破裂或皱缩；局灶性胞浆疏松、水肿；胞浆内空泡增多，细胞器离散、数目减少。内皮细胞生成和释放的６－ｋｅｔｏ－ＰＧＦ１α明显降低，ＡＣＥ、ＥＴ和ｆⅧＲ：Ａｇ显著增加。猪发生远达效应后，其４、６ｈ血清也可使ＶＥＣ结构和功能发生类似改变，但没有扰动流体所致ＶＥＣ结构和功能的改变严重。提示高速投射物致伤机体瞬间，循环管路内剧烈扰动的流体已可造成远隔部位组织脏器微血管内皮的损伤，这可能为远达效应的发生创造了条件。创伤后神经体液因子的改变则促使这种损伤进一步加剧，并为创伤后某些严重并发症的发生发展提供了病理形态学和病理生理学基础 The effects of transient fluid disturbances and wound sera on the cultured porcine aortic endothelial cells (VECs) were observed by in vitro simulated circulation and far-reaching effect animal models. The effects of these two traumatic factors on VEC relationship. Discovering the fluid perturbations caused by the high velocity projectile can significantly alter the structure and function of the VEC. VEC film showed rupture or shrinkage; focal cytoplasm loose, edema; cytoplasmic vacuoles increased, organelles discrete, the number decreased. 6-keto-PGF1α produced and released by endothelial cells was significantly reduced, while ACE, ET and fⅧR: Ag were significantly increased. Pig far effect, the 4,6 h serum VEC also make the structure and function of a similar change, but did not disturb the fluid caused by changes in VEC structure and function of serious. Prompt high-speed projectiles cause injury to the body at the moment, the violent disturbance of circulation pipeline fluid can cause distant parts of tissue and organ microvascular endothelial damage, which may create the conditions for the far effect. Post-traumatic changes in neurohumoral factors contribute to further aggravate the injury and provide a basis for pathological and pathophysiological studies on the occurrence and development of some serious complications after trauma