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目的:探讨CXCR4在结肠直肠癌组织中的表达及其临床意义。方法:应用S-P免疫组织化学方法检测63例结肠直肠癌组织、25例癌旁正常组织、17例肝转移灶和15例淋巴结转移灶中CXCR4的表达。结果:与癌旁正常组织相比,结肠直肠癌组织表达较高水平的CXCR4。CXCR4的高表达与结肠直肠癌患者的年龄、性别、结肠直肠癌组织类型、分化程度无关,而与临床转移有关。结论:CXCR4上调表达与结肠直肠癌的发生和转移有关。
Objective: To investigate the expression of CXCR4 in colorectal cancer and its clinical significance. Methods: The expression of CXCR4 was detected by S-P immunohistochemistry in 63 cases of colorectal cancer, 25 cases of adjacent normal tissues, 17 cases of liver metastases and 15 cases of lymph node metastases. Results: Colorectal cancer tissues expressed higher levels of CXCR4 than normal tissues. The high expression of CXCR4 and colorectal cancer patients age, gender, colorectal cancer tissue type, the degree of differentiation has nothing to do, but with clinical metastasis. Conclusion: Up-regulated expression of CXCR4 is associated with the occurrence and metastasis of colorectal cancer.